Germ cells and genital ridges.

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Events in the germ cell lineage after entry of the primordial germ cells into the genital ridges in normal and u.v.-irradiated Xenopus laevis.

Approximately 20-25 primordial germ cells leave the endoderm between stages 38-41 and localize in the dorsal root of the mesentery by stage 43/44. At this time all the cells contain large quantities of yolk which is gradually resorbed. The cells begin dividing between stages 48-52. The number and size of the germ cells were measured in tadpoles between stages 48-54 of development. The results i...

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Genital ridges exert long-range effects on mouse primordial germ cell numbers and direction of migration in culture.

The functional gametes of all vertebrates first arise in the early embryo as a migratory population of cells, the primordial germ cells (PGCs). These migrate to, and colonise, the genital ridges (GR) during the early organogenesis period, giving rise to the complete differentiating gonad. PGCs first become visible by alkaline phosphatase staining in the root of the developing allantois at 8.5 d...

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Sex differentiation is a process that starts early during embryogenesis. In males, the SRY gene, located in the short arm of chromosome Y, encodes for the testis-determining factor, which causes the gonad to differentiate into testis. Testicular androgen synthesis by Leydig cells starts from the eighth week of development. It is initially stimulated by placental chorionic gonadotropin (HCG), an...

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from stem cells to germ cells and from germ cells to stem cells

germline and somatic stem cells are distinct types of stem cells that are dedicated to reproduction and somatic tissue regeneration, respectively. germline stem cells (gscs), which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. we developed a strategy for the establishment of germline st...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1970

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.45.243.708-a